Last week's homework for Growing Venture Solution's Introduction to Drupal 6 presented me with an opportunity to install my first Drupal multi-site on my test website, vfranklyn.com. I don't normally work in a LAMP environment, so this was a real learning experience for me.
Fortunately, Drupal.org's rockin' community had some excellent documentation:
Multi-site setup in 6.x using cPanel
Of course, I had to wait several hours for the domain name to propagate, but hw.vfranklyn.com is up and running (although quite lame as it is a homework assignment.